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Effects of 4-HNE on cartilage homeostasis and subchondral bone 4-HNE is one of the secondary metabolites of oxidation of PUFAs, particularly omega-6 fatty acids such as arachidonic acid and linoleic acid [75]

The molecule is planar

Focal Adhesion Kinase (FAK) and paxillin are crucial proteins involved in focal adhesions, which are dynamic structures that mediate cell attachment to the extracellular matrix and play a pivotal role in cell spreading and migration

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